Innovative companies in the international pharmaceutical market

Authors

DOI:

https://doi.org/10.31617/2.2025(53)01

Keywords:

innovations, international pharmaceutical market, R&D (research and developments), patents, generic, global marketing, innovative marketing.

Abstract

Increasing the role of the global imperative of health care as a benchmark for the civilizational development of mankind in the modern era creates a strong demand for achievement of high performance in the inno­vative sector of contemporary pharma­ceuticals. At the same time, the innovation process is a complex and high-risk phenomenon, which depends on the interaction of a number of factors. The preliminary research hypothesis presented in this article is the thesis on the conditionality of innovations in the interna­tional pharmaceutical business by the contra­dictory influence of factors of both external (exogenous) and internal (endogenous) origin and their significant external consequences for global healthcare, economic development and social welfare. The purpose of the article is to disclose the exogenous determinants of innova­tive development of companies in the interna­tional pharmaceutical market. To accomplish the task, a complex of methods of scientific knowledge, which contains analysis and synthesis, comparative analysis and syste­matization, is applied. To obtain substan­tiated conclusions, the study was based on the CASE STUDY method and empirical-statistical analysis. The study showed that the pharmaceutical business is currently one of the most dynamic and innovation-oriented sectors of the global economy, which has received additional impetus for its development in the conditions of COVID-19, revolutionary shifts in the system of fundamental science, active integration of artificial intelligence into research and pro­duction processes. The assessment of indivi­dual regulatory levers of influence on the activities of pharmaceutical companies has shown some differences in national regimes for regulation and maintenance of innovative activity in the pharmaceutical sector, in parti­cular regarding the practice of direct R&D subsidization, the scale of the spread of reimbursement mechanisms, the intellectual property protection, etc. The analysis also demonstrated that marketing technologies have a strong impact on the implementation of pharma­ceutical companiesʼ innovation priorities, in particular, due to the active implementation of product life cycle strategies, the continua­tion of market exclusivity and the protection of monopolistic drug sales is achieved. Future research prospects are considered in terms of the analysis of economic mechanisms for the inclusion of national companies in the global chains of new drug development and production, directions of increasing the investment attracti­veness of the domestic pharmaceutical sector for leading non-resident companies, which are leaders of the international market.

Author Biography

Liudmyla KUDYRKO, State University of Trade and Economics

PhD (Economics), Professor, Professor at the Department of World Economy

References

Arnold Ventures. (2020, September 24). "Evergreening" Stunts Competition, Costs Consumers and Taxpayers. https://www.arnoldventures.org/stories/evergreening-stunts-competition-costs-consumers-and-taxpayers

Asad, A. I., & Homolka, L. (2023). Investing in innovation: The relationship between R&D spending and financial performance in the European pharmaceutical industry. Journal of Eastern European and Central Asian Research, 10(7), 1006-1026. https://ieeca.org/journal/index.php/JEECAR/article/view/1368

Bin Sawad, A., & Turkistani, F. (2021). Pharmaceutical Marketing Transformation due to COVID-19 Pandemic. Journal of Pharmaceutical Research International, (33), 91-99. https://doi.org/10.9734/jpri/2021/v33i33A31776

Brough, W. (2024). The Economics of the Pharmaceutical Sector: Innovation, Competition, and Patent Policy. RStreet. https://www.rstreet.org/commentary/the-economics-of-the-pharmaceutical-sector-innovation-competition-and-patent-policy/

Buntz, B. (2024, April 30). Top pharma companies ranked by 2023 R&D spend. https://www.drugdiscoverytrends.com/top-pharma-companies-2023-rd-spend

CBO. (2021, April). Research and Development in the Pharmaceutical Industry. https://www.cbo.gov/system/files/2021-04/57025-Rx-RnD.pdf

CRS. (2020, February 11). Drug Pricing and Pharmaceutical Patenting Practices. Report. https://www.everycrsreport.com/reports/R46221.html

De la Torre, B. G., & Albericio, F. (2024). The Pharmaceutical Industry in 2023: An Analysis of FDA Drug Approvals from the Perspective of Molecules. Molecules, 29(3), 585. https://doi.org/10.3390/molecules29030585

DeRuiter, J., & Holston, P. L. (2012). Drug Patent Expirations and the "Patent Cliff". U.S. Pharm, 37(6), 12-20. https://www.uspharmacist.com/article/drug-patent-expirations-and-the-patent-cliff

Dutta, Soumitra, Lanvin, Bruno, Rivera León, Lorena, & Wunsch-Vincent, Sacha. (2024). Global Innovation Index 2024: Unlocking the Promise of Social Entrepreneurship. WIPO. https://doi.org/10.34667/tind.50062

Dutton, G. (2022). Looming Patent Cliff will be Pharmaʼs Moment of Truth. Biospace. https://www.biospace.com/looming-patent-cliff-will-be-pharma-s-moment-of-truth

Esparcia, C., & López, R. (2022). Outperformance of the pharmaceutical sector during the COVID-19 pandemic: Global time-varying screening rule development. Information Sciences, (609), 1181-1203. https://doi.org/10.1016/j.ins.2022.07.146

Harsha, Kumar, A. S., Jwalapuram, S., & Kumar, S. (2023). Marketing strategies in the pharmaceutical industry. The Scientific Temper, (14), 1526-1530. https://doi.org/10.58414/SCIENTIFICTEMPER.2023.14.4.67

IQVIA. (2024, January 16). The Global Use of Medicines 2024: Outlook to 2028. Report. https://www.iqvia.com/insights/the-iqvia-institute/reports-and-publications/reports/the-global-use-of-medicines-2024-outlook-to-2028

Jalilova, A. (2024). Strategy to increase the share of sales in the pharmaceutical market. Economics of Development, 23(1), 53-61. https://doi.org/10.57111/econ/1.2024.53

Kuchler, H. (2021). Novavax closes in on COVID triumph after 33 years of failure. Financial Times. https://www.ft.com/content/22d3805e-c304-4d95-ae32-f559ff34886a

Maragkou, I. (2024). The worldʼs biggest pharmaceutical companies: Top ten by revenue. Pharmaceutical Technology. https://www.pharmaceutical-technology.com/features/top-ten-pharma-companies-in-2023/?cf-view

Mikulic, M. (2023, December 19). AI in the pharmaceutical industry. https://www.statista.com/topics/11820/ai-in-pharmaceutical-industry/#topicOverview

Murray, C. et al. (2022). Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet, 399(10325), 629-655. https://doi.org/10.1016/S0140-6736(21)02724-0

OECD. (n. d. a). Research and Development Statistics (RDS). https://www.oecd.org/en/data/datasets/research-and-development-statistics.html

OECD. (n. d. b). Public subsidies for pharmaceutical R&D. https://www.oecd.org/en/topics/pharmaceuticals-and-medical-technologies.html

Statista. (2022). Percentage of spending on research and development of total revenue in 2022, by industrial sector. https://www.statista.com/statistics/270324/expenditure-on-research-and-development-by-industry-sectors/

Statista. (2022, May 22). Pharmaceutical market: worldwide revenue 2001-2023. https://www.statista.com/statistics/263102/pharmaceutical-market-worldwide-revenue-since-2001/

Statista. (2023, December 15). Index of AI readiness of select big pharma companies as of 2023. https://www.statista.com/statistics/1428819/big-pharma-ai-readiness-index/

Statista. (2024, October 9). Number of European patents granted in medical technology 2023, by country. https://www.statista.com/statistics/1000661/european-patents-granted-in-medtech/

Statista. (2024, September 17). Market share of leading 10 national pharmaceutical markets worldwide in 2023. https://www.statista.com/statistics/245473/market-share-of-the-leading-10-global-pharmaceutical-markets/

Statista. (2025, January). Pharmaceuticals: market data & analysis. https://www.statista.com/study/123522/pharmaceuticals-market-data-and-analysis/

Timanyuk, I., Bondarieva, I., & Malyi, V. (2022). Digitalization of Pharmaceutical Business in Ukraine. Research Journal of Pharmacy and Technology, 1555-1559. https://doi.org/10.52711/0974-360X.2022.00259

USPTO. (2024). United States Code Title 35 - Patents. https://www.uspto.gov/web/offices/pac/mpep/mpep-9015-appx-l.html#d0e303023313

WHO. (‎2018). Medicines reimbursement policies in Europe. https://iris.who.int/handle/10665/342220

WHO. (2024, October 1). Ageing and health. https://www.who.int/news-room/fact-sheets/detail/ageing-and-health

World Bank. (n. d.). Drug-Resistant Infections: A Threat to Our Economic Future. DC: World Bank. https://www.worldbank.org/en/topic/health/publication/drug-resistant-infections-a-threat-to-our-economic-future

Duginets, G., & Nizheiko, K. (2024). Innovative marketing of strategic alliances in the international pharmaceutical market. Digital Есопоmу and Economic Security, 6(15), 167-173. https://doi.org/10.32782/dees.15-26

Zholudenko, T. (2024). The role of innovative marketing in the development of the international pharmaceutical market. Actual Problems of Economics, 6(276), 217-227. https://doi.org/10.32752/1993-6788-2024-1-276-217-227

Zadorozhniuk, N., Malysh, I., & Minieieva, Ya. (2020). Specifics of marketing in the pharmaceutical industry. Scientific Bulletin of Mukachevo State University, 1(13), 86-91. https://doi.org/10.31339/2313-8114-2020-1(13)-86-91

Kudyrko, L. (2024). Marketing priorities of companies in the international pharmaceutical market. Economic space, (193), 53-59. https://doi.org/10.30838/EP.193.53-59

Kuzmynchuk, N., Kutsenko, T., Koval, V., & Bondar, V. (2020). Marketing of medicines in the context of state regulation of the pharmaceutical market. Central Ukrainian Scientific Bulletin. Series: Economic Sciences, 5(38), 190-196. https://doi.org/10.32515/2663-1636.2020.5(38).190-196

Melnychenko, О. (2024). Marketing digital tools in the promotion of pharmaceutical brands. Foreign trade: economics, finance, law, 136(5), 98-109. https://doi.org/10.31617/3.2024(136)07

Published

2025-03-12

How to Cite

[1]
KUDYRKO Л. 2025. Innovative companies in the international pharmaceutical market. INTERNATIONAL SCIENTIFIC-PRACTICAL JOURNAL COMMODITIES AND MARKETS. 53, 1 (Mar. 2025), 4–24. DOI:https://doi.org/10.31617/2.2025(53)01.